Biology of Oral Cancer

Biology of Oral Cancer

Key Apoptotic Regulators

Bisen, Prakash S.; Bundela, Saurabh (Department of Post Graduate Studies and Research in Biological Sciences, Rani Durgawati University, Jabalpur, India); Khan, Zakir (Institut Curie, Unit TGF-ss and Oncogenesis, CNRS UMR3347 / INSERM U1021, Centre Universitaire, Orsay, France)

Taylor & Francis Ltd






15 a 20 dias

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Cancer: A Worldwide Menace Epidemiology Diagnosis and Pathology Conclusion References Oral Cancer Key Words Introduction Epidemiology Signs and Symptoms Sex and Age Distribution Etiology Pathology Staging Individual Cancers of the Oral Cavity Conclusion References Proliferative and Apoptotic Signaling in Oral Cancer Key Words Introduction Regulation of Cell Homeostasis Somatic Gene Mutation Oncogenes and Tumor Suppressors NF- B Serine/Threonine Kinases Steroid Hormones Central Role of Caspases Caspases Inhibitory Proteins Death Domains Fas/Fas Ligand TRAIL and Its Receptors Conclusion References Apoptotic Regulations Key Words Introduction Etymology Mechanisms of Apoptosis in Cancer Role of Apoptotic Regulators in Rheumatoid Arthritis (RA) Role of Apoptotic Regulators in Prostate Carcinoma Conclusion References Dynamics of p53 in Oral Cancer Key Words Introduction Functions and Roles in Causing Disease p53 as an Oncogene p53 as a Tumor Suppressor Mutations in p53 Apoptotic Regulation by p53 Interplay between Survivin and p53 Clinicopathological Significance of p53 Therapeutic Strategies Targeting p53 Conclusion References Diagnostic and Therapeutic Potential of Apoptotic Marker Key Words Introduction Apoptotic Markers in Oral Cancer Therapeutics Apoptotic Markers in Oral Cancer Diagnostics Conclusion References Expression and Regulation of Survivin Key Words Introduction Molecular Organization and Structure of Survivin Functions of Survivin Regulation of Survivin Anti-Apoptotic Network of Survivin Expression of Survivin in Normal Tissues Expression of Survivin in Human Cancer Conclusion References Therapeutics of Survivin Key Words Introduction Manipulation of the Survivin Gene Factors Inducing Survivin Expression Downregulation of Survivin Ribozyme-Mediated Degradation of Survivin Immunotherapy Therapeutic Biology of Survivin Survivin-Directed Cancer Therapy Regulation of Survivin in Head and Neck Squamous Carcinoma Prognostic and Diagnostic Significance of Survivin Therapeutic Approach Survivin for Cancer Immunotherapy Conclusion References Molecular Diagnosis of Oral Cancer Key Words Introduction Molecular Markers for Oral Cancer Molecular Mechanism of Development of Oral Cancer The Hallmarks of Oral Cancer Other Markers Diagnosis of Oral Squamous Cell Carcinoma Conclusion References Glossary Index
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